In Swedish
| Title | Can resting-state functional MRI serve as a complement to task-based mapping of sensorimotor function? A test-retest reliability study in healthy volunteers. |
| Author/s | Peter Mannfolk, Markus Nilsson, Henrik Hansson, Freddy Ståhlberg, Peter Fransson, Andreas Weibull, Jonas Svensson, Ronnie Wirestam, Johan Olsrud |
| Department/s |
Radiation Physics, Lund
Medical Radiation Physics, Malmö Diagnostic Radiology, (Lund) |
| Full-text | Full text is not available in this archive |
| Alternative location (URL) | http://www.ncbi.nlm.nih.gov/pu... Restricted Access (Alternative Location) |
| Alternative location (URL) | http://dx.doi.org/10.1002/jmri... Restricted Access (Alternative Location) |
| Publication/Series | Journal of magnetic resonance imaging : JMRI |
| Publishing year | 2011 |
| Volume | 34 |
| Pages | 511 - 517 |
| Document type | Journal article |
| Status | published |
| Quality controlled | yes |
| Language | English |
| Abstract English | PURPOSE: To investigate if resting-state functional MRI (fMRI) reliably can serve as a complement to task-based fMRI for presurgical mapping of the sensorimotor cortex. MATERIALS AND METHODS: Functional data were obtained in 10 healthy volunteers using a 3 Tesla MRI system. Each subject performed five bilateral finger tapping experiments interleaved with five resting-state experiments. Following preprocessing, data from eight volunteers were further analyzed with the general linear model (finger tapping data) and independent component analysis (rest data). Test-retest reliability estimates (hit rate and false alarm rate) for resting-state fMRI activation of the sensorimotor network were compared with the reliability estimates for task-evoked activation of the sensorimotor cortex. The reliability estimates constituted a receiver operating characteristics curve from which the area under the curve (AUC) was calculated. Statistical testing was performed to compare the two groups with respect to reliability. RESULTS: The AUC was generally higher for the task experiments, although median AUC was not significantly different on a group level. Also, the two groups showed comparable levels of within-group variance. CONCLUSION: Test-retest reliability was comparable between resting-state measurements and task-based fMRI, suggesting that presurgical mapping of functional networks can be a supplement to task-based fMRI in cases where patient status excludes task-based fMRI. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc. |
| Subject |
Medicine and Health Sciences |
| ISBN/ISSN/Other |
ISSN: 1522-2586 |
Last modified 19 Apr 2013
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