In Swedish
| Title | Apparent exchange rate mapping with diffusion MRI. |
| Author/s | Samo LasiÄ, Markus Nilsson, Jimmy Lätt, Freddy StÃ¥hlberg, Daniel Topgaard |
| Department/s |
Diagnostic Radiology, (Lund)
Radiation Physics, Lund |
| Full-text | Full text is not available in this archive |
| Alternative location (URL) | http://www.ncbi.nlm.nih.gov/pu... Restricted Access (Alternative Location) |
| Alternative location (URL) | http://dx.doi.org/10.1002/mrm.... Restricted Access (Alternative Location) |
| Publication/Series | Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine |
| Publishing year | 2011 |
| Volume | 66 |
| Pages | 356 - 365 |
| Document type | Journal article |
| Status | published |
| Quality controlled | yes |
| Language | English |
| Abstract English | Water exchange through the cell membranes is an important feature of cells and tissues. The rate of exchange is determined by factors such as membrane lipid composition and organization, as well as the type and activity of aquaporins. A method for noninvasively estimating the rate of water exchange would be useful for characterizing pathological conditions, e.g., tumors, multiple sclerosis, and ischemic stroke, expected to be associated with a change of the membrane barrier properties. This study describes the filter exchange imaging method for determining the rate of water exchange between sites having different apparent diffusion coefficients. The method is based on the filter-exchange pulsed gradient spin-echo NMR spectroscopy experiment, which is here modified to be compatible with the constraints of clinical MR scanners. The data is analyzed using a model-free approach yielding maps of the apparent exchange rate, here being introduced in analogy with the concept of the apparent diffusion coefficient. Proof-of-principle experiments are performed on microimaging and whole-body clinical scanners using yeast suspension phantoms. The limitations and appropriate experimental conditions are examined. The results demonstrate that filter exchange imaging is a fast and reliable method for characterizing exchange, and that it has the potential to become a powerful diagnostic tool. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. |
| Subject |
Medicine and Health Sciences |
| ISBN/ISSN/Other |
ISSN: 1522-2594 |
Last modified 19 Apr 2013
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